Jiehui Deng

This study identifies M1C as a driver of sotorasib resistance in NSCLC KRAS G12C mutant tumors and shows that targeting M1C improves treatment outcomes.

This study shows that aneuploidy promotes ROS resistance by suppressing PARP1, which enhances metastasis, and identifies CEBPB as a key mediator of this process.

This paper introduces DD-CIPs, bivalent molecules that induce DNA damage response and apoptosis in cancer cells, showing efficacy against PARPi-resistant cancers.

This study shows that inhibiting DNA polymerase epsilon in TNBC triggers an NF-κB-driven inflammatory response and tumor clearance in mice.

This study identifies EGFR mutations conferring resistance to BLU-945 using deep mutational scanning and shows that combination treatment may suppress resistance mechanisms.

The paper introduces a segmentation-free vision transformer, CANVAS, to discover and characterize tumor microenvironment signatures from high-dimensional multiplexed images, identifying a monocytic signature linked to poor prognosis.