Deep Mutational Scanning Reveals EGFR Mutations Conferring Resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945
Yueyang Wang, Yuan Hao, Michela Ranieri, Tigran M. Abramyan, Lev Tsidilkovski, Michelle Hollenberg, Alfonso Lopez, Xavier T.R. Moore, Fiona Sherman, Jiehui Deng, Hayk Saribekyan, Garegin A. Papoian, Kwok‐Kin Wong, Elaine Shum, John Thomas Poirier
This study identifies EGFR mutations conferring resistance to BLU-945 using deep mutational scanning and shows that combination treatment may suppress resistance mechanisms.
npj Precision Oncology · Aug 20, 2025Peer-reviewedCancer Biology