Inhibition of PfCLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malaria
Omar Janha, Niniola Olaniyan, Ka Diam Go, Saumya Sharma, Dario Beraldi, Andrew G. Jamieson, Zbynek Bozdech, Andrew B. Tobin, Katarzyna Modrzynska
This study shows that inhibiting PfCLK3 disrupts RNA-splicing in malaria parasites, affecting 1125 genes and providing a novel mechanism for a radical cure.
bioRxiv · Oct 7, 2025 · PreprintMolecular Biology