Author

Nishtha Chitkara

National University of Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Ahmed M. MamdouhiD· 1 shared Anthony G. LetaiiD· 1 shared Daniel Tan En Liang· 1 shared Elyse A. OlesinskiiD· 1 shared Fang Qi Lim· 1 shared Koji ItahanaiD· 1 shared Leah J. Hogdal· 1 shared Nicole Si En Lin· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ahmed M. MamdouhORCID

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1 paper

Recent·Most cited

TP53 mutations drive therapy resistance via post-mitochondrial caspase blockade

Ahmed M. Mamdouh, Elyse A. Olesinski, Fang Qi Lim, Shaista Shabbir Jasdanwala, Yang Mi, Nicole Si En Lin, Daniel Tan En Liang, Nishtha Chitkara, Leah J. Hogdal, Robert Coleman Lindsley, Anthony G. Letai, Koji Itahana, Shruti Bhatt

This study identifies that TP53 mutations in AML lead to resistance to VenAza therapy by blocking caspase-3/7 activation after mitochondrial outer membrane permeabilization.

bioRxiv · Aug 28, 2025 · PreprintCancer Biology