Robert Coleman Lindsley

MEDUSA improves sequencing accuracy by minimizing DNA duplex resynthesis during library preparation, achieving lower residual SNV frequency in genomic and cell-free DNA.

The paper identifies recipient stem-cell persistence and T-cell dysregulation as predictors of relapse after HSCT in AML/MDS by analyzing single-cell RNA and TCR sequencing data.

This study identifies that TP53 mutations in AML lead to resistance to VenAza therapy by blocking caspase-3/7 activation after mitochondrial outer membrane permeabilization.

This study identifies secondary genetic events in KMT2A-PTD patients, showing their association with disease progression and higher RNA expression.

The paper identifies TERT rare variants in MDS patients, showing shorter telomeres, younger age at diagnosis, and worse survival, suggesting their role in MDS pathogenesis and transplant outcomes.