Author

Fang Qi Lim

National University of Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ahmed M. MamdouhiD· 3 shared Shruti BhattiD· 3 shared Chuqi WangiD· 2 shared Edward AyoubiD· 2 shared Elyse A. OlesinskiiD· 2 shared Jordan Yong Ming TaniD· 2 shared Karanpreet Singh BhatiaiD· 2 shared Koji ItahanaiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Ahmed M. MamdouhORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)

Chuqi Wang, Yuhan Wang, Camillo Benetti, Xiao Xian Lin, Enes Dasdemir, Petra Hyroššová, Jordan Yong Ming Tan, Edward Ayoub, Karanpreet Singh Bhatia, Fang Qi Lim, Yun Li, Zihui Zhao, Ahmed M. Mamdouh, Shir Ying Lee, Jakub Rohlena, , Shruti Bhatt

This study identifies that macrophage-secreted pyrimidine metabolites confer chemotherapy resistance in AML by inhibiting drug activation, and shows that targeting macrophage metabolism can restore drug sensitivity.

bioRxiv · Nov 1, 2025 · PreprintCancer Biology

TP53 mutations drive therapy resistance via post-mitochondrial caspase blockade

Ahmed M. Mamdouh, Elyse A. Olesinski, Fang Qi Lim, Shaista Shabbir Jasdanwala, Yang Mi, Nicole Si En Lin, Daniel Tan En Liang, Nishtha Chitkara, Leah J. Hogdal, Robert Coleman Lindsley, Anthony G. Letai, Koji Itahana, Shruti Bhatt

This study identifies that TP53 mutations in AML lead to resistance to VenAza therapy by blocking caspase-3/7 activation after mitochondrial outer membrane permeabilization.

bioRxiv · Aug 28, 2025 · PreprintCancer Biology

BIRC5 dependency defines a targetable vulnerability in TP53 mutant acute myeloid leukemia

Ahmed M. Mamdouh, Fang Qi Lim, Yang Mi, Elyse A. Olesinski, Shaista Shabbir Jasdanwala, Xiao Xian Lin, Edward Ayoub, Jordan Yong Ming Tan, Karanpreet Singh Bhatia, Yichen Wang, Shradha Garnaik, Kunal Tomar, Valeriia Sapozhnikova, Cheryl Gek Teng Chan, Chuqi Wang, , Shruti Bhatt

This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.

bioRxiv · May 17, 2025 · PreprintCancer Biology