MDMA enhances prefrontal plasticity and representational drift during fear extinction
Nitzan Geva, Sarah J. Jefferson, Emi Krishnamurthy, Tanner L. Anderson, Jocelyne A. Rondeau, Patrick H. Wehrle, Axel Fogaça Rosado, Christopher Pittenger, John H. Krystal, Alfred P. Kaye
This study shows MDMA increases prefrontal spine density and enhances functional connectivity during fear extinction, leading to accelerated representational drift in specific neurons.
bioRxiv · Mar 8, 2026 · PreprintNeuroscience