Alfred P. Kaye

This study shows human claustrum neurons encode uncertainty and prediction errors during aversive learning, with distinct temporal profiles compared to anterior cingulate cortex.

The paper investigates how amygdala beta bursts influence hippocampal activity during emotional processing in humans, finding they suppress hippocampal firing during negative emotional stimuli.

This study shows that innate avoidance of heights is refined by noradrenergic signaling and prefrontal cortex experience, without external reinforcement.

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.

This study shows MDMA increases prefrontal spine density and enhances functional connectivity during fear extinction, leading to accelerated representational drift in specific neurons.

This study uses two-photon microscopy to show that NE and ACh transients have distinct spatiotemporal dynamics during decision-making in mice, with NE promoting exploration.

The paper classifies psychedelics and psychoactive drugs using brain-wide imaging of c-Fos expression and machine learning, achieving above-chance accuracy in drug identification.

The paper records claustrum neurons during human sleep and finds they increase activity and track slow waves during NREM sleep.

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

The paper investigates how spatiotemporal dynamics of norepinephrine release in the prefrontal cortex affect neuronal firing and finds that local NE fields can drive cell firing independently of global fields during decoupling.

The paper investigates neuromodulator dynamics in mice during a naturalistic reward-threat task, finding distinct roles for norepinephrine, dopamine, and serotonin in encoding motivational states.

This study investigates the behavioral and neural effects of 5-MeO-DMT in mice, showing dose-dependent changes in behavior and long-term dendritic spine density increases without affecting spine size.

This study identifies norepinephrine as a threat prediction error signal during fear learning, contrasting with dopamine's role in reward prediction.