Author

John H. Krystal

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alfred P. KayeiD· 2 shared Christopher PittengeriD· 2 shared Jocelyne A. Rondeau· 2 shared Sarah J. JeffersoniD· 2 shared Abigail L. YuiD· 1 shared Alan AnticeviciD· 1 shared Aleksandar SavićiD· 1 shared Alex C. KwaniD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersNeuroscience

Alfred P. KayeORCID

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Author profile →

5 papers

Recent·Most cited

Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision

Masih Rahmati, Flora Moujaes, Nina Purg, Jie Lisa Ji, Lucie Berkovitch, Kangjoo Lee, Clara Fonteneau, Charles H. Schleifer, Brendan D. Adkinson, Aleksandar Savić, Nicole P. Santamauro, Zailyn Tamayo, Caroline Diehl, Antonija Kolobaric, Morgan Flynn, , Alan Anticevic

This study shows ketamine broadens neural spatial tuning and impairs spatial working memory in healthy humans, linking NMDAR antagonism to cortical microcircuit disruptions.

Biological Psychiatry · Sep 1, 2026Peer-reviewedNeuroscience

Enhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response

Gabriele Floris, Sarah J. Jefferson, Jocelyne A. Rondeau, Abigail L. Yu, Frank S. Menniti, Alex C. Kwan, João Paulo De Aquino, John H. Krystal, Christopher Pittenger, Alfred P. Kaye

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.

bioRxiv · Apr 16, 2026 · PreprintNeuroscience

MDMA enhances prefrontal plasticity and representational drift during fear extinction

Nitzan Geva, Sarah J. Jefferson, Emi Krishnamurthy, Tanner L. Anderson, Jocelyne A. Rondeau, Patrick H. Wehrle, Axel Fogaça Rosado, Christopher Pittenger, John H. Krystal, Alfred P. Kaye

This study shows MDMA increases prefrontal spine density and enhances functional connectivity during fear extinction, leading to accelerated representational drift in specific neurons.

bioRxiv · Mar 8, 2026 · PreprintNeuroscience

Neural patterns differentiate traumatic from sad autobiographical memories in PTSD

Ofer Perl, Or A. Duek, Kaustubh R. Kulkarni, Ben Kelmendi, Shelley L. Amen, Charles Gordon, John H. Krystal, Ifat Levy, Ilan Harpaz‐Rotem, Daniela Schiller

This study identifies distinct neural patterns in PTSD patients for traumatic versus sad memories, showing divergent hippocampal representations and symptom severity effects in the posterior cingulate cortex.

Nature Neuroscience · Nov 30, 2023Peer-reviewedNeuroscience

Transcriptomic Organization of Human Posttraumatic Stress Disorder

Matthew J. Girgenti, Jiawei Wang, Dingjue Ji, Dianne A. Cruz, the Million Veteran Program, Murray B. Stein, Joel E. Gelernter, Keith Young, Bertrand R. Huber, Douglas E. Williamson, Matthew J. Friedman, John H. Krystal, Hongyu Zhao, Ronald S. Duman

This study identifies transcriptomic changes and genetic factors associated with PTSD using postmortem brain tissue and GWAS data, revealing sex differences and divergence from MDD.

Nature Neuroscience · Dec 21, 2020Peer-reviewedGenomics