Christopher Pittenger

This study shows human claustrum neurons encode uncertainty and prediction errors during aversive learning, with distinct temporal profiles compared to anterior cingulate cortex.

The paper investigates how amygdala beta bursts influence hippocampal activity during emotional processing in humans, finding they suppress hippocampal firing during negative emotional stimuli.

This paper introduces a Hodge-Laplacian framework to analyze higher-order topology in OCD brain networks, identifying loop-level abnormalities not detectable by conventional functional connectivity analysis.

The paper proposes a dynamic biosocial model of hypomanic vulnerability, linking neural mechanisms to behavioral and social factors, and presents preliminary evidence of neural reconfiguration in hypomanic tendencies.

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.

This study shows MDMA increases prefrontal spine density and enhances functional connectivity during fear extinction, leading to accelerated representational drift in specific neurons.

The paper investigates if value-based evidence accumulation, measured via drift rate, is more strongly linked to general distress than to specific psychiatric symptoms.

The paper investigates sex differences in behavioral outcomes of early life stress in mice, identifying circuit-specific effects in the medial prefrontal cortex.

The paper records claustrum neurons during human sleep and finds they increase activity and track slow waves during NREM sleep.

The paper examines sex differences in the density and distribution of striatal interneurons in male and female mice, finding higher CIN density in males and a greater dorsal-ventral gradient in males for FSIs.

This study investigates sex differences in histamine's regulation of striatal dopamine, finding that histamine decreases dopamine in males but increases it in females, with estrous cycle modulation in females.

The paper introduces a naive Bayes classifier to automate grooming behavior analysis in mice using force-plate actometry, achieving high accuracy and demonstrating its utility in tic disorder models.

This study shows that depletion of PFC GFAP+ astroglia induces anhedonia-like behavior, while their activation reverses stress-induced anhedonia, highlighting their role in depression.

This study investigates the behavioral and neural effects of 5-MeO-DMT in mice, showing dose-dependent changes in behavior and long-term dendritic spine density increases without affecting spine size.

Neurospectrum extracts interpretable spatiotemporal features from neural activity using a geometric and topological deep learning framework, outperforming traditional methods in simulations and fMRI data.

The paper develops a stable brain-behavior space mapping for psychosis-spectrum disorders using symptom and brain data, showing univariate approaches outperform multivariate ones for individualized prediction.

This study identifies white matter microstructural alterations in adult OCD patients and links them to clinical features, while finding no such abnormalities in pediatric patients.

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

This study shows that a Shank3 mutation causes elevated calcium in dendritic spines due to reduced inhibition from SST interneurons, and correcting this improves learning deficits.

This study shows that ketamine suppresses SST interneurons, leading to increased calcium signals in dendritic spines of pyramidal neurons in the medial prefrontal cortex of awake mice.