Sarah J. Jefferson

Enhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.

MDMA enhances prefrontal plasticity and representational drift during fear extinction

This study shows MDMA increases prefrontal spine density and enhances functional connectivity during fear extinction, leading to accelerated representational drift in specific neurons.

5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice

This study investigates the behavioral and neural effects of 5-MeO-DMT in mice, showing dose-dependent changes in behavior and long-term dendritic spine density increases without affecting spine size.