Loss of cell cycle gatekeeping by 1 CNOT3 impairs hematopoietic stem and progenitor cell division and repopulating activity
Katie A. Yuen, Thilelli Taibi, Quang Anh Hoang, Marty Yue, Zongmin Liu, Effat Habibi, Elias Spiliotopoulos, Niveditha Ramkumar, Nick Nation, Glenn Edin, Thuy T. M. Ngo, Ly Vu
This study shows that CNOT3 deletion in HSCs causes anemia, reduced bone marrow cellularity, and impaired hematopoietic reconstitution.
bioRxiv · Oct 23, 2025 · PreprintDevelopmental Biology