Kumarasamy Thangaraj K

An Atlas of Indian Genetic Diversity

The paper presents a comprehensive genomic atlas of Indian populations, identifying novel variants and highlighting genetic diversity and pharmacogenomic implications.

Revisiting the Evolution of Lactase Persistence: Insights from South Asian Genomes

This study analyzes South Asian genomes to understand the evolutionary history of lactase persistence, finding that Steppe ancestry, not selection, explains most LP prevalence, with exceptions in two pastoralist groups.

Investigating the demographic history of Sindhi population inhabited in West coast India

The paper analyzes the genetic structure of a Sindhi population in West coast India, finding significant genetic affinity with the Burusho group and evidence of recent admixture with the Konkani population.

An efficient protocol to derive primordial germ cell like cells in vitro from murine embryonic stem cells.

This paper develops an optimized protocol to improve the efficiency of in vitro differentiation of primordial germ cell-like cells from mouse embryonic stem cells using ascorbic acid.

Genetic affinities and sub-structuring in Coorg population of Southern India

This study investigates the genetic structure and demographic history of the Coorg population in Southern India using autosomal and uniparental markers, revealing ancient origins and population substructure.

Endogamy and high prevalence of deleterious mutations in India: evidence from strong founder events

The paper analyzes whole-exome sequencing data from South Indian populations to identify founder events and deleterious mutations, revealing high inbreeding rates and population-specific pathogenic variants.

Maternal genetic affinities of Konkani population in the southwest coast of India

The paper analyzes maternal genetic diversity in the Konkani population of India using mitogenomes, revealing distinct haplogroups and historical migration patterns.

Genetic architecture and adaptation of Ladakh highlanders of trans-Himalayas

This study genotypes 80 Ladakh individuals to analyze genetic lineages, admixture, and adaptation, finding distinct East Asian and Indo-European affinities with signals of high-altitude and immunity adaptation.

Genetic affinities and adaptation of the South West coast populations of India

This study analyzes genetic admixture and adaptation in South West coast India populations, revealing distinct lineage and early migration patterns from North West India.

TEX13B is important for germ cell development and male fertility

The paper investigates the role of TEX13B in male infertility by analyzing genetic variants and functional effects in germ cells.

Invivo and systematic analysis of random multigenic deletions associated with human diseases during epithelial morphogenesis using Drosophila

The paper uses Drosophila deficiency lines to analyze multigenic deletions and their implications in human diseases related to epithelial morphogenesis and cytoskeletal processes.

A distinct phylogenetic cluster of Indian SARS-CoV-2 isolates

The paper analyzes SARS-CoV-2 genomes from India, identifying a distinct phylogenetic cluster (Clade I/A3i) that accounts for 41% of Indian isolates and 3.5% globally.