Author

Shanmugasundaram Pakkiriswami

University of MinnesotaORCID 0000-0002-7191-8199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alia Kazim Rizvi Syeda· 1 shared Barry E. Kennedy· 1 shared Brian A. Harsch· 1 shared Chastity L. HealyiD· 1 shared Cory J. Benson· 1 shared Dylan J. GybergiD· 1 shared Gregory C. SheareriD· 1 shared Julia C. LiuiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

Alia Kazim Rizvi Syeda

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3 papers

Recent·Most cited

Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy

Michael J. Zhang, Sara J. Puccini, Sergey Karachenets, Dylan J. Gyberg, Shanmugasundaram Pakkiriswami, Megan K. Sumera, Ryan Gemilere, Natalie L. Weir, Sebastian L Torres, Chastity L. Healy, Brian A. Harsch, Steven C. Wu, Julia C. Liu, Gregory C. Shearer, Timothy D. O’Connell

This study shows that Ffar4 in cardiac myocytes reduces systolic dysfunction after ischemia-reperfusion by improving mitochondrial function and cGMP signaling.

Cardiovascular Research · Aug 14, 2026Peer-reviewedPhysiology

TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance

Alia Kazim Rizvi Syeda, Shekoufeh Almasi, Cory J. Benson, Barry E. Kennedy, Ryan M. Yoast, Scott M. Emrich, Logan Slade, Shanmugasundaram Pakkiriswami, Vishnu Vijay Vijayan, Shashi Ashok Gujar, Thomas Pulinilkunnil, Mohamed Trebak, Yassine El Hiani

This study identifies TRPML1 as a key regulator of mitochondrial function and chemoresistance in TNBC by modulating lysosomal-mitochondria signaling and autophagy.

bioRxiv · Sep 11, 2025 · PreprintCancer Biology

Invivo and systematic analysis of random multigenic deletions associated with human diseases during epithelial morphogenesis using Drosophila

Usha Nagarajan, Shanmugasundaram Pakkiriswami, Sandiya Srinivasan, Niveditha Ramkumar, Rajeswari Rajaraman, Kumarasamy Thangaraj K

The paper uses Drosophila deficiency lines to analyze multigenic deletions and their implications in human diseases related to epithelial morphogenesis and cytoskeletal processes.

bioRxiv · Jan 20, 2021 · PreprintGenetics