Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of mitochondria
Niyaz Zaman, Natasha Aley, Valeria Pingitore, David L. Selwood, Robin Ketteler
This paper introduces ULK1-Recruiting Chimeras (ULKRECs) that induce ULK1-dependent mitophagy, showing efficacy in Parkinson's fibroblasts independent of the PRKN/PINK axis.
bioRxiv · Apr 15, 2024 · PreprintCell Biology