Robin Ketteler

Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase

This study investigates how LAAO causes cellular destruction by disrupting multiple organelles, leading to energy failure and cell death.

Compound screening in primary human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

ATG5 is dispensable for ATG8ylation of cellular proteins

The paper investigates the mechanism of protein ATG8ylation, showing that ATG5 is dispensable for this process, unlike its role in lipid ATG8ylation.

Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of mitochondria

This paper introduces ULK1-Recruiting Chimeras (ULKRECs) that induce ULK1-dependent mitophagy, showing efficacy in Parkinson's fibroblasts independent of the PRKN/PINK axis.

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

The paper investigates USP30 inhibition's role in enhancing Parkin-mediated mitophagy using pharmacological and genetic approaches in cellular models.

Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells

This paper corrects FKRP mutations in iPSCs using CRISPR/Cas9, restoring functional glycosylation of α-dystroglycan in cortical neurons and validating the role of FKRP in dystroglycanopathies.