CD24 Acts as an Evolutionarily Conserved Innate Immune Checkpoint in Colorectal Cancer
Ana Beatriz Machado, Cátia Rebelo de Almeida, Catarina M. Azevedo, Nuno Viana, Diogo R. Fernandes, Vanda Póvoa, Francisco Marques, Rita Zilhão, June Ereño‐Orbea, Jesús Jiménez‐Barbero, Ana Rita Carlos, Salomé S. Pinho, Rita Fior
This study identifies CD24 as an innate immune checkpoint in colorectal cancer that promotes tumor survival by inhibiting macrophage-mediated clearance, validated through zebrafish models and human data.
bioRxiv · Aug 26, 2026 · PreprintCancer Biology