Rita Fior

This study identifies CD24 as an innate immune checkpoint in colorectal cancer that promotes tumor survival by inhibiting macrophage-mediated clearance, validated through zebrafish models and human data.

This study shows that enhancing HLA-DR expression in cytotoxic T lymphocytes improves their anti-tumor activity, suggesting strategies to optimize adoptive T cell therapies for breast cancer.

The paper develops a zebrafish model to predict breast cancer patient response to chemotherapy, showing perfect correlation between patient and model treatment outcomes.

This paper introduces PSEs, bifunctional molecules that enhance phagocytosis and block PD-L1, showing improved antitumor responses in animal models.

This study identifies macrophages as key drivers of BCG therapy's anti-tumoral effect through direct TNF-mediated cancer cell killing, independent of adaptive immunity.