Author

O. Andrisani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. Yan· 2 shared J. Sun· 2 shared M. Kazemian· 2 shared P. Merle· 2 shared S. Utturkar· 2 shared A. Foca· 1 shared C. Caron de Fromentel· 1 shared D. Durantel· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

B. Yan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

Z. Li, J. Sun, N. Rahman, B. Yan, S. Utturkar, N. A. Lanman, M. Kazemian, C. Caron de Fromentel, M. Levrero, O. Andrisani

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

bioRxiv · Mar 31, 2022 · PreprintCancer Biology

RNA helicase DDX5 enables STAT1 mRNA translation and interferon signaling in hepatitis B virus replicating hepatocytes

J. Sun, G. Wu, W.-H. Wang, Z. Zhang, P. Merle, L. Hui, D. Yang, O. Andrisani

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

bioRxiv · Sep 25, 2020Cancer Biology

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma

S. K. Kailasam Mani, Z. Cui, B. Yan, S. Utturkar, A. Foca, N. Fares, D. Durantel, N. Lanman, P. Merle, M. Kazemian, O. Andrisani

This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.

bioRxiv · Sep 12, 2019 · PreprintCancer Biology