Author

P. Merle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1

Frequent Co-Authors

O. Andrisani· 2 shared A. Foca· 1 shared B. Yan· 1 shared C. Caron de Fromentel· 1 shared D. Durantel· 1 shared D. Yang· 1 shared E. Bestion· 1 shared E. P. Gifu· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

O. Andrisani

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Author profile →

3 papers

Recent·Most cited

GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer

S. Brun, J.-M. Pascussi, E. P. Gifu, E. Bestion, Z. Macek-Jilkova, G. Wang, F. Bassissi, S. Mezouar, J. Courcamberck, P. Merle, T. Decaens, J. Pannequin, P. Halfon, C. Caron de Fromentel

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

bioRxiv · Dec 21, 2020Cancer Biology

RNA helicase DDX5 enables STAT1 mRNA translation and interferon signaling in hepatitis B virus replicating hepatocytes

J. Sun, G. Wu, W.-H. Wang, Z. Zhang, P. Merle, L. Hui, D. Yang, O. Andrisani

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

bioRxiv · Sep 25, 2020Cancer Biology

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma

S. K. Kailasam Mani, Z. Cui, B. Yan, S. Utturkar, A. Foca, N. Fares, D. Durantel, N. Lanman, P. Merle, M. Kazemian, O. Andrisani

This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.

bioRxiv · Sep 12, 2019 · PreprintCancer Biology