Cancer BiologybioRxivPreprint
RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer
Z. Li, J. Sun, N. Rahman…·O. Andrisani
This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.
DOI 10.1101/2022.03.31.486452