Author

J. A. Kennedy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1 Ecology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. E. Dick· 4 shared M. D. Minden· 4 shared A. G. X. Zeng· 3 shared A. Mitchell· 3 shared E. R. Lechman· 2 shared L. Jin· 2 shared N. Mbong· 2 shared O. I. Gan· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCancer Biology

J. E. Dick

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

A. G. X. Zeng, I. Iacobucci, S. Shah, A. Mitchell, G. Wong, S. Bansal, D. Chen, Q. Gao, H. Kim, J. A. Kennedy, M. D. Minden, T. Haferlach, C. G. Mullighan, J. E. Dick

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

bioRxiv · Dec 26, 2023Cancer Biology

Novel TRPM7 inhibitors with potent anti-inflammatory effects in vivo

G. W. Busey, M. C. Manjegowda, T. Huang, W. H. Iobst, S. S. Naphade, J. A. Kennedy, C. A. Doyle, P. V. Seegren, K. R. Lynch, B. N. Desai

This study identifies novel TRPM7 inhibitors with potent in vivo anti-inflammatory effects, showing efficacy in a mouse model of endotoxemia.

bioRxiv · May 22, 2023 · PreprintImmunology

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

L. D. Boila, S. Ghosh, S. K. Bandyopadhyay, L. Jin, A. Murison, A. G. X. Zeng, W. Shaikh, S. Bhowmik, S. S. N. A. Muddineni, M. Biswas, S. Sinha, S. S. Chatterjee, N. Mbong, O. I. Gan, A. Bose, , A. Sengupta

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

bioRxiv · Jul 12, 2022 · PreprintCancer Biology

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

A. G. X. Zeng, S. Bansal, L. Jin, A. Mitchell, W. C. Chen, H. A. Abbas, M. Chan-Seng-Yue, V. Voisin, P. van Galen, A. Tierens, M. Cheok, C. Preudhomme, H. Dombret, N. Daver, P. A. Futreal, , J. E. Dick

This study identifies a cellular hierarchy framework in AML that links disease heterogeneity with drug response and develops a 7-gene biomarker predictive of drug sensitivity.

bioRxiv · Jan 25, 2022Cancer Biology

The colonial legacy of herbaria

D. S. Park, X. Feng, S. Akiyama, M. Ardiyani, N. Avendano, Z. Barina, B. Bartschi, M. Belgrano, J. Betancur, R. Bijmoer, A. Bogaerts, A. Cano, J. Danihelka, A. Garg, D. E. E. Giblin, , Slette

The paper analyzes 85 million herbarium records to show colonial legacies in plant specimen distribution, revealing disparities between biodiversity hotspots and where specimens are housed.

bioRxiv · Oct 27, 2021Ecology

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

A. L. H. Webster, M. A. Sanders, K. Patel, R. Dietrich, R. J. Noonan, F. P. Lach, R. R. White, A. Goldfarb, K. Hadi, M. M. Edwards, F. X. Donovan, M. Jung, S. Sridhar, O. Fedrigo, H. Tian, , P. Campbell

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

bioRxiv · Aug 14, 2021 · PreprintCancer Biology

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

G. Krivdova, V. Voisin, E. M. Schoof, S. A. Marhon, A. J. Murison, J. L. McLeod, M. Gabra, A. G. Zeng, E. L. Van Nostrand, S. J. Aigner, A. A. Shishkin, B. A. Yee, K. G. Hermans, A. G. Trotman-Grant, N. Mbong, , E. R. Lechman

This study identifies miR-130a as a regulator of HSC self-renewal and differentiation, with TBL1XR1 as a key target, and shows its role in maintaining the oncogenic program in t(8;21) AML.

bioRxiv · Jul 30, 2021Cell Biology

Back to the future: a refined single user photostation for massively scaling herbarium digitization

C. C. Davis, J. A. Kennedy, C. J. Grassa

This paper introduces a novel photostation design for herbarium specimen digitization that improves efficiency and scalability for institutions of all sizes.

bioRxiv · Sep 9, 2020Plant Biology