A. H. Laustsen

mRNA-delivered consensus allergens induce a neutralizing IgG response against food and pollen allergens

This study shows that mRNA-delivered consensus allergens induce neutralizing IgG responses against multiple food and pollen allergens, offering a safer and broader allergy immunotherapy approach.

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

Phage display assisted discovery of a pH-dependent anti-alpha-cobratoxin antibody from a natural variable domain library

The paper discovers a pH-dependent anti-alpha-cobratoxin antibody from a natural variable domain library without histidine doping, showing that pH-dependency can arise without histidine residues.

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

Discovery of broadly-neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens

This study develops a high-throughput method to discover broadly-neutralizing antibodies against venom toxins using consensus antigens, showing improved success in cross-neutralization compared to traditional methods.

Prototyping of a lateral flow assay based on monoclonal antibodies for detection of Bothrops venoms

This paper describes a prototype lateral flow assay using monoclonal antibodies to detect Bothrops venoms, achieving a limit of detection of 8.0 ng/mL in serum and 9.5 ng/mL in urine.

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

Black-necked spitting cobra (Naja nigricollis) phospholipases A2 cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket

This study shows that phospholipases A2 from Black-necked spitting cobra venom block Trypanosoma brucei endocytosis by enlarging the flagellar pocket and disrupting Rab11 localization, leading to cell cycle arrest.