Y. Cong

Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera

The paper uses hamster sera to map antigenic differences among SARS-CoV-2 variants, showing JN.1 has significant antigenic divergence from XBB.1.5.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Cryo-EM of α-tubulin isotype containing microtubules revealed a contracted structure of α4A/β2A microtubules

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

Broadly neutralizing antibodies target the coronavirus fusion peptide

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

Molecular basis of SARS-CoV-2 Omicron variant receptor engagement and antibody evasion and neutralization

This study investigates the structural basis of SARS-CoV-2 Omicron variant's immune evasion and transmissibility using cryo-EM, revealing conformational changes and enhanced ACE2 binding.

The cryo-EM structure of the chloroplast ClpP complex reveals an interaction with the co-chaperonin complex that inhibits ClpP proteolytic activity

The paper determines the cryo-EM structure of the chloroplast ClpP complex and shows how the co-chaperonin inhibits its proteolytic activity.

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

Cryo-EM study on the homo-oligomeric ring formation of yeast TRiC/CCT subunits reveals TRiC ring assembly mechanism

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

Cryo-EM of mammalian PA28αβ-iCPimmunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

Transcriptome analysis of the Nematode Caenorhabditis elegans in acidic stress environments

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

Signature activities of 20S proteasome include degradation of the ubiquitin-tag with the protein under hypoxia

The paper identifies the 20S proteasome's ability to degrade ubiquitin-tagged proteins under hypoxia and shows its role in improving cell survival.

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

The paper reveals the structure and composition of the mouse axonemal radial spoke head using cryo-EM, showing distinct subunit composition and organization compared to Chlamydomonas.

A complex structure of arrestin-2 bound to a G protein-coupled receptor

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

Hetero-oligomeric CPN60 resembles highly symmetric group I chaperonin structure revealed by Cryo-EM

The paper reveals the structure of the chloroplast chaperonin system using Cryo-EM, showing its hetero-oligomeric composition and functional properties.