O. Majer

Endosome dysfunction leads to gain-of-function TLR7 and human lupus

This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.

Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity

This study identifies a mechanism by which Unc93b1 recruits Syntenin-1 to specifically inhibit TLR7 signaling and prevent autoimmunity.