Author

D. Meierhofer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell-cell communication· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Rabien· 2 shared B. Timmermann· 2 shared E. Kilic· 2 shared J. F. Busch· 2 shared K. Jung· 2 shared M. Attimonelli· 2 shared R. Clima· 2 shared S. Villegas· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Rabien

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Endosome dysfunction leads to gain-of-function TLR7 and human lupus

H. Mishra, C. Schlack-Leigers, E. L. Lim, O. Thieck, T. Magg, J. Raedler, C. Wolf, C. Klein, H. Ewers, M. A. Lee-Kirsch, D. Meierhofer, F. Hauck, O. Majer

This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.

bioRxiv · Apr 3, 2023 · PreprintImmunology

Rational optimization of a transcription factor activation domain inhibitor

S. Basu, P. Martinez-Cristobal, M. Pesarrodona, M. Frigole-Vivas, E. Szulc, M. Lewis, A. Banuelos, C. Sanchez-Zarzalejo, S. Bielskute, J. Zhu, K. Pombo-Garcia, C. Garcia-Cabau, C. Batlle, B. Mateos, M. Biesaga, , X. Salvatella

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

bioRxiv · Aug 18, 2022Biochemistry

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

L. Jiao, R. Eickhoff, S. Jumpertz, J. Roth, M. Erdem, A. Kroh, H. Duimel, C. Lopez Iglesias, M. Schmeding, L. R. Heij, D. Meierhofer, U. P. Neumann, T. Cramer

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

bioRxiv · Aug 6, 2020 · PreprintCancer Biology

The effects of arbuscular mycorrhizal fungi (AMF) and Rhizophagus irregularis on soil microorganisms assessed by metatranscriptomics and metaproteomics

D. Lammel, D. Meierhofer, P. R. Johnston, S. Mbedi, M. C. Rillig

This study investigates how AMF and Rhizophagus irregularis influence soil microorganisms using metatranscriptomics and metaproteomics, revealing their role in soil metabolism and nutrient cycling.

bioRxiv · Dec 10, 2019 · PreprintEcology

Papillary renal cell carcinomas rewire glutathione metabolism and are deficient in anabolic glucose synthesis

A. Alahmad, V. Paffrath, R. Clima, J. F. Busch, A. Rabien, E. Kilic, S. Villegas, B. Timmermann, M. Attimonelli, K. Jung, D. Meierhofer

This study identifies metabolic reprogramming in papillary renal cell carcinomas, including increased glutathione synthesis and reduced anabolic glucose synthesis.

bioRxiv · May 27, 2019Cancer Biology

Metabolic reprogramming and elevation of glutathione in chromophobe renal cell carcinomas

Y. Xiao, R. Clima, J. F. Busch, A. Rabien, E. Kilic, S. Villegas, S. Tuerkmen, B. Timmermann, M. Attimonelli, K. Jung, D. Meierhofer

This study identifies metabolic reprogramming and elevated glutathione in chromophobe renal cell carcinomas through multi-omics profiling.

bioRxiv · May 24, 2019 · PreprintCancer Biology