Author

C. Schlack-Leigers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

H. Ewers· 2 shared C. Klein· 1 shared C. Matthaus· 1 shared C. Wolf· 1 shared D. Meierhofer· 1 shared D. Puchkov· 1 shared E. L. Lim· 1 shared F. Hauck· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

H. Ewers

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Adhesion energy controls lipid binding-mediated endocytosis

R. Groza, K. V. Schmidt, P. M. Muller, P. Ronchi, C. Schlack-Leigers, U. Neu, D. Puchkov, R. Dimova, C. Matthaus, J. W. Taraska, T. Weikl, H. Ewers

The paper shows that multivalent lipid binding by globular particles induces membrane deformation and clathrin-independent endocytosis, with adhesion energy determining the threshold for internalization.

bioRxiv · Jun 23, 2023Biophysics

Endosome dysfunction leads to gain-of-function TLR7 and human lupus

H. Mishra, C. Schlack-Leigers, E. L. Lim, O. Thieck, T. Magg, J. Raedler, C. Wolf, C. Klein, H. Ewers, M. A. Lee-Kirsch, D. Meierhofer, F. Hauck, O. Majer

This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.

bioRxiv · Apr 3, 2023 · PreprintImmunology