Author

M. A. Lee-Kirsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. A. Hyman· 1 shared A. Chhabra· 1 shared A. Rapp· 1 shared C. Klein· 1 shared C. Schlack-Leigers· 1 shared C. Wolf· 1 shared D. Kuster· 1 shared D. Meierhofer· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. A. Hyman

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Author profile →

2 papers

Recent·Most cited

Endosome dysfunction leads to gain-of-function TLR7 and human lupus

H. Mishra, C. Schlack-Leigers, E. L. Lim, O. Thieck, T. Magg, J. Raedler, C. Wolf, C. Klein, H. Ewers, M. A. Lee-Kirsch, D. Meierhofer, F. Hauck, O. Majer

This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.

bioRxiv · Apr 3, 2023 · PreprintImmunology

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

S. Maharana, S. Kretschmer, S. Hunger, X. Yan, D. Kuster, S. Traikov, T. Zillinger, N. Chappidi, N. Lucas, K. I. Maser, H. Maatz, A. Rapp, V. Marchand, V. Iyer, A. Chhabra, , M. A. Lee-Kirsch

This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.

bioRxiv · Jul 12, 2022Immunology