Author

M. Ikura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Liu· 1 shared A. S. Flozak· 1 shared A. Yemelyanov· 1 shared A.-C. Gingras· 1 shared B. Domingo· 1 shared C. B. Marshall· 1 shared C. D. Go· 1 shared C. Ferec· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. Liu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

Y. J. Wang, A. Yemelyanov, C. D. Go, S. Kim, J. M. Quinn, A. S. Flozak, P. M. Le, S. Liang, A.-C. Gingras, M. Ikura, N. Ishiyama, C. J. Gottardi

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Journal of Cell Biology · Jan 9, 2025Peer-reviewedCell Biology

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry

p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis.

M. Burgos, R. Phillipe, F. Antigny, P. Buscaglia, E. Masson, S. Mukherjee, P. Dubar, C. Le Marechal, F. Campeotto, N. Lebonvallet, M. Frieden, J. Llopis, B. Domingo, P. B. Stathopulos, M. Ikura, , O. Mignen

The paper identifies a p.E152K-STIM1 mutation that disrupts Ca2+ signaling in pancreatic acinar cells, leading to trypsin activation and cell death in pancreatitis patients.

bioRxiv · Jan 22, 2020Cell Biology

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

M. Inoue, M. Enomoto, Y. Koike, M. A. Di Grappa, X. Zhao, K. Yip, S. H. Huang, J. N. Waldron, M. Ikura, F.-F. Liu, S. V. Bratman

This study shows that albumin oxidation causes redox imbalance, leading to inflammation-independent NETosis and lung-specific cancer metastasis.

bioRxiv · Feb 28, 2018Cancer Biology