O. Perez-Leal

Identification of tubulin polymerization inhibitors with a CRISPR-edited cell line with endogenous fluorescent tagging of β-tubulin and Histone 1

This study uses CRISPR-edited cells with fluorescent β-tubulin to identify three novel tubulin polymerization inhibitors from a kinase inhibitor library.

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

This study identifies secreted folate receptor-gamma (FOLR3) as a driver of fibrogenesis in NASH by enhancing TGFβ signaling in hepatic stellate cells.