Early intervention with a PACAP lactoside following repetitive mild traumatic brain injury prevents persistent LHb hyperactivity and motivational deficits in male mice
Emily H. Thomas, Troy E. Smith, Lajos Z. Szabò, William J. Flerlage, Fahad Al‐Obeidi, Oana L. Rujan, Shawn Gouty, Regina C. Armstrong, Brian M. Cox, Torsten Falk, Michael L. Heien, Chidiebere Ogbu, Minying Cai, Mitchell J. Bartlett, Robin L. Polt, Fereshteh S. Nugent
This study shows that early administration of a PACAP agonist prevents mTBI-induced LHb hyperactivity and motivational deficits in mice, while late administration has limited efficacy and potential side effects.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience