William J. Flerlage

This study shows that early administration of a PACAP agonist prevents mTBI-induced LHb hyperactivity and motivational deficits in mice, while late administration has limited efficacy and potential side effects.

This study identifies a novel population of CRF-expressing lateral habenula neurons in mice and characterizes their sex-specific behavioral and electrophysiological properties.

This study investigates how repetitive mild traumatic brain injury (mTBI) affects corticotropin-releasing factor (CRF) modulation of lateral habenula (LHb) excitability and motivated behavior in male and female mice, revealing sex-specific neurobehavioral effects.

This study investigates how repetitive mild traumatic brain injury (mTBI) affects Kappa Opioid Receptor (KOR) neuromodulation of lateral habenula (LHb) synaptic function in male and female mice, revealing changes in excitatory/inhibitory balance.

This study investigates the role of AKAP150 in regulating synaptic transmission, plasticity, and CRF neuromodulation in the lateral habenula using genetic and electrophysiological approaches.

This study shows that repetitive mTBI causes LHb neuronal dysfunction, leading to motivational deficits, and that inhibiting LHb activity can reverse these deficits.

This study shows that early life stress alters kappa opioid receptor signaling in the lateral habenula, affecting neuronal excitability and synaptic transmission in rat models.