Regina C. Armstrong

This study shows that early administration of a PACAP agonist prevents mTBI-induced LHb hyperactivity and motivational deficits in mice, while late administration has limited efficacy and potential side effects.

This study identifies a novel population of CRF-expressing lateral habenula neurons in mice and characterizes their sex-specific behavioral and electrophysiological properties.

This study evaluates [18F]3F4AP PET imaging for detecting demyelination in traumatic brain injury models in mice, showing increased tracer uptake correlating with histological evidence of myelin loss.

This study investigates how repetitive mild traumatic brain injury (mTBI) affects corticotropin-releasing factor (CRF) modulation of lateral habenula (LHb) excitability and motivated behavior in male and female mice, revealing sex-specific neurobehavioral effects.

This study investigates how prolonged stress and sex differences affect sleep-wake dysfunction in mice following repetitive mild traumatic brain injury.

This study shows that repetitive mTBI causes LHb neuronal dysfunction, leading to motivational deficits, and that inhibiting LHb activity can reverse these deficits.

This study tests 4-aminopyridine as an acute treatment for traumatic brain injury, finding it reduces axon damage and demyelination in preclinical models.

This study shows that genetic inactivation of SARM1 reduces axonal damage and improves functional outcomes after traumatic brain injury.

This study shows that transplanted adult neural stem cells reduce neuroinflammation after TBI but do not activate host Shh signaling via Gli1 transcription.