Shawn Gouty

Early intervention with a PACAP lactoside following repetitive mild traumatic brain injury prevents persistent LHb hyperactivity and motivational deficits in male mice

This study shows that early administration of a PACAP agonist prevents mTBI-induced LHb hyperactivity and motivational deficits in mice, while late administration has limited efficacy and potential side effects.

Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice

This study identifies a novel population of CRF-expressing lateral habenula neurons in mice and characterizes their sex-specific behavioral and electrophysiological properties.

Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior

This study investigates how repetitive mild traumatic brain injury (mTBI) affects corticotropin-releasing factor (CRF) modulation of lateral habenula (LHb) excitability and motivated behavior in male and female mice, revealing sex-specific neurobehavioral effects.

Dysregulation of Kappa Opioid Receptor Neuromodulation of Lateral Habenula Synaptic Function following a Repetitive Mild Traumatic Brain Injury

This study investigates how repetitive mild traumatic brain injury (mTBI) affects Kappa Opioid Receptor (KOR) neuromodulation of lateral habenula (LHb) synaptic function in male and female mice, revealing changes in excitatory/inhibitory balance.

AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula

This study investigates the role of AKAP150 in regulating synaptic transmission, plasticity, and CRF neuromodulation in the lateral habenula using genetic and electrophysiological approaches.

Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits

This study shows that repetitive mTBI causes LHb neuronal dysfunction, leading to motivational deficits, and that inhibiting LHb activity can reverse these deficits.

Blast-induced mild traumatic brain injury alterations of corticotropin-releasing factor neuronal activity in the mouse hypothalamic paraventricular nucleus

This study investigates how blast-induced mild traumatic brain injury (mbTBI) affects corticotropin-releasing factor (CRF) neuronal activity in the mouse hypothalamic paraventricular nucleus (PVN), finding increased firing in dorsal PVN CRF neurons and associated GABAergic synaptic dysfunction.

Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats

This study shows that early life stress increases glutamatergic synaptic activity in the lateral habenula, which persists into adulthood and reduces morphine intake and reward behavior in rats.

Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

This study shows that early life stress alters kappa opioid receptor signaling in the lateral habenula, affecting neuronal excitability and synaptic transmission in rat models.