Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology
Lauren M. Vetere, Angelina Galas, Nick Vaughan, Cassidy Kohler, Yu Feng, Zoé Christenson Wick, Paul A. Philipsberg, Olga Liobimova, Kathryn E. Gordon, Antonio Fernández‐Ruiz, Denise J. Cai, Tristan Shuman
The paper examines neural activity in the medial entorhinal cortex and hippocampus of 3xTg mice, finding that reduced theta power and coherence, along with disrupted phase locking, coincide with the onset of spatial memory impairment in a model of Alzheimer's disease.
Cell Reports · Jul 1, 2026Peer-reviewedNeuroscience