Denise J. Cai

The paper examines neural activity in the medial entorhinal cortex and hippocampus of 3xTg mice, finding that reduced theta power and coherence, along with disrupted phase locking, coincide with the onset of spatial memory impairment in a model of Alzheimer's disease.

This study shows that grooming increases after stress when danger is absent, indicating it reflects post-stress recovery rather than a defensive response.

The paper introduces GLOBE, a brain-wide single-cell recording technology, and demonstrates its use in capturing Fos transcriptional activity across a mouse brain over time.

The paper shows that state-dependent geometric transformations in the mouse hippocampus enable fear generalization without losing context discriminability.

This paper introduces CytoTape, a tool for continuous, multiplexed recording of gene regulation dynamics over weeks at single-cell resolution, and demonstrates its use in measuring transcription factor activities.

This study demonstrates that inhibitory theta phase locking in interneurons directly controls seizure susceptibility using a closed-loop optogenetic system.

This study examines how hippocampal and medial entorhinal circuit dysfunction evolves with cognitive deficits in epilepsy using in vivo electrophysiology in mice.

This paper introduces chemotagging, a method to identify specific cell types in vivo calcium imaging using chemogenetic tools, enabling long-term tracking of neuronal populations.

This study identifies an anterior hypothalamic circuit that modulates stress vulnerability by integrating valence signals from the amygdala.

The paper investigates how stress-induced plasticity in the amygdala and ventral hippocampus differentially supports non-associative defensive behaviors.

This paper introduces a dual-channel miniscope for simultaneous two-wavelength calcium imaging in freely behaving mice, showing spatial coding changes over time.

The paper examines excitability changes in the medial entorhinal cortex of 3xTg mice at early and late stages of Alzheimer's disease pathology, finding hyperexcitability in specific cell types and altered synaptic ratios.

Chronotate is an open-source tool for manually scoring rodent behavior videos, providing detailed temporal data to analyze interaction patterns in novel object tasks.

The paper introduces a model showing that slow fluctuations in intrinsic excitability drive neural ensemble drift, which is necessary for decoding temporal information.

This study shows that strong aversive experiences in mice drive offline reactivation of both recent aversive and older neutral memories, linking them across days.

The paper investigates age-related changes in neuronal excitability in the hippocampus of mice, finding that aged mice show a deficit in ensemble-specific excitability after learning, linked to memory impairment.

This study identifies a mechanism where hippocampal ensembles are remodeled to support memory-updating in mice during spatial reversal tasks.

Minian is an open-source pipeline for analyzing single-photon in vivo calcium imaging data, offering low memory usage, interactive visualizations, and parameter exploration tools.

This paper shows that delayed CCR5 expression after memory formation limits the temporal window for linking memories by reducing neuronal overlap in mice.

ezTrack provides an open-source video analysis pipeline for animal behavior studies, offering tools for tracking and freezing behavior analysis without requiring programming expertise.

This study investigates spatial coding and neural synchronization in epilepsy using in vivo calcium imaging and network modeling, finding impaired spatial processing and desynchronized firing in epileptic mice.