Paul A. Philipsberg

Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology

The paper examines neural activity in the medial entorhinal cortex and hippocampus of 3xTg mice, finding that reduced theta power and coherence, along with disrupted phase locking, coincide with the onset of spatial memory impairment in a model of Alzheimer's disease.

Interneuron theta phase locking controls seizure susceptibility

This study demonstrates that inhibitory theta phase locking in interneurons directly controls seizure susceptibility using a closed-loop optogenetic system.

Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy

This study examines how hippocampal and medial entorhinal circuit dysfunction evolves with cognitive deficits in epilepsy using in vivo electrophysiology in mice.

Simultaneous dual-color calcium imaging in freely-behaving mice

This paper introduces a dual-channel miniscope for simultaneous two-wavelength calcium imaging in freely behaving mice, showing spatial coding changes over time.

Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology

The paper examines excitability changes in the medial entorhinal cortex of 3xTg mice at early and late stages of Alzheimer's disease pathology, finding hyperexcitability in specific cell types and altered synaptic ratios.

Chronotate: An open-source tool for manual timestamping and quantification of animal behavior

Chronotate is an open-source tool for manually scoring rodent behavior videos, providing detailed temporal data to analyze interaction patterns in novel object tasks.

Manipulating single-unit theta phase-locking with PhaSER: An open-source tool for real-time phase estimation and manipulation