Tristan Shuman

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

The paper examines neural activity in the medial entorhinal cortex and hippocampus of 3xTg mice, finding that reduced theta power and coherence, along with disrupted phase locking, coincide with the onset of spatial memory impairment in a model of Alzheimer's disease.

This study demonstrates that inhibitory theta phase locking in interneurons directly controls seizure susceptibility using a closed-loop optogenetic system.

This study examines how hippocampal and medial entorhinal circuit dysfunction evolves with cognitive deficits in epilepsy using in vivo electrophysiology in mice.

The paper investigates how stress-induced plasticity in the amygdala and ventral hippocampus differentially supports non-associative defensive behaviors.

This paper introduces a dual-channel miniscope for simultaneous two-wavelength calcium imaging in freely behaving mice, showing spatial coding changes over time.

The paper examines excitability changes in the medial entorhinal cortex of 3xTg mice at early and late stages of Alzheimer's disease pathology, finding hyperexcitability in specific cell types and altered synaptic ratios.

Chronotate is an open-source tool for manually scoring rodent behavior videos, providing detailed temporal data to analyze interaction patterns in novel object tasks.

This study shows that strong aversive experiences in mice drive offline reactivation of both recent aversive and older neutral memories, linking them across days.

The paper investigates age-related changes in neuronal excitability in the hippocampus of mice, finding that aged mice show a deficit in ensemble-specific excitability after learning, linked to memory impairment.

This study identifies a mechanism where hippocampal ensembles are remodeled to support memory-updating in mice during spatial reversal tasks.

Minian is an open-source pipeline for analyzing single-photon in vivo calcium imaging data, offering low memory usage, interactive visualizations, and parameter exploration tools.

ezTrack provides an open-source video analysis pipeline for animal behavior studies, offering tools for tracking and freezing behavior analysis without requiring programming expertise.

This study investigates the effects of CNTNAP2 loss-of-function mutations in mice, finding reduced synaptic connectivity and altered oscillatory dynamics in the prefrontal cortex associated with autism-like behaviors.

This study investigates spatial coding and neural synchronization in epilepsy using in vivo calcium imaging and network modeling, finding impaired spatial processing and desynchronized firing in epileptic mice.