Cassidy Kohler

The paper examines neural activity in the medial entorhinal cortex and hippocampus of 3xTg mice, finding that reduced theta power and coherence, along with disrupted phase locking, coincide with the onset of spatial memory impairment in a model of Alzheimer's disease.

This study demonstrates that inhibitory theta phase locking in interneurons directly controls seizure susceptibility using a closed-loop optogenetic system.