T cell receptor-ligand affinity quantitatively tunes transcriptome remodelling in vivo, inversely regulating cell division and interferon response
Veera Panova, Andrew Muir, Erick Armingol, Oliver Burton, Jessica L. Quantrill, David A. Lewis, Simon J. Cook, Martin Turner, Adrian Liston, Roser Vento-Tormo, Arianne C. Richard
This study shows that TCR-ligand affinity quantitatively modulates transcriptome remodelling in vivo, affecting cell division and interferon response.
bioRxiv · Jun 30, 2026 · PreprintImmunology