Endothelial Cell Expression of STINGV154M Gain-of-Function Mutation Delays the Resolution of UVB-induced Skin Injury
Jane Chuprin, Carolina Salomão Lopes, Kevin MingJie Gao, Kristy Chiang, Khashayar Afshari, Nazgol‐Sadat Haddadi, Mridushi Daga, Olivia Dekker, Manuel G. Garber, Milka Koupenova, Katherine A. Fitzgerald, Ann Marshak‐Rothstein, Mehdi Rashighi
This study shows that endothelial cells with a STINGV154M mutation cause persistent skin inflammation after UVB exposure, linking STING activation to impaired myeloid cell recruitment and delayed inflammation resolution.
Journal of Investigative Dermatology · Mar 28, 2026Peer-reviewedImmunology