The autism-associated loss of δ-catenin functions disrupts social behaviors
Hadassah Mendez-Vazquez, Regan L. Roach, Kaila Nip, Soham Chanda, Matheus Figueiredo Sathler, Tyler Garver, Rosaline A. Danzman, Madeleine C. Moseley, Jessica P. Roberts, Olivia N. Koch, Ava A. Steger, Rahmi Lee, Jyothi Arikkath, Seonil Kim
This paper investigates how the G34S mutation in δ-catenin causes loss of function leading to social dysfunction in ASD by altering glutamatergic activity and GSK3β-mediated degradation.
Proceedings of the National Academy of Sciences · May 22, 2023Peer-reviewedNeuroscience