Author

Jonathan W. Bushman

Amgen (United States)ORCID 0000-0002-8230-6315Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alex Golkar· 1 shared Alex Rosa CamposiD· 1 shared Alyssa L. VeranoiD· 1 shared Amber D. Senese· 1 shared Amit VaishiD· 1 shared Anastasia Velentza· 1 shared Andrew Burritt· 1 shared Animesh Chandra RoyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Alex Golkar

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2 papers

Recent·Most cited

Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics

Kheewoong Baek, Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin, Julia K. Ryan, Dinah M. Abeja, Megha Lakshminarayan, Hong Yue, Samuel Ojeda, Yuan Xiong, Jianwei Che, Alyssa L. Verano, Anna M. Schmoker, , Eric S. Fischer

The paper identifies 298 protein targets of CRBN-binding molecular glues using a high-throughput affinity purification mass spectrometry workflow and demonstrates a lead compound for the new target PPIL4.

Nature Communications · Jul 24, 2025Peer-reviewedCancer Biology

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq

Jonathan W. Bushman, Weixian Deng, Kusal T. G. Samarasinghe, Han‐Yuan Liu, Shiqian Li, Amit Vaish, Alex Golkar, Shu Ou, Jinwoo Ahn, Rajesh K. Harijan, Han Han, Tomas Duffy, Elliot Imler, Judy Qiju Wu, Reneé Rawson, , Patrick Ryan Potts

The paper discovers a VHL molecular glue degrader of GEMIN3 using Picowell RNA-seq screening, showing how it targets GEMIN3 for degradation through ternary complex formation.

bioRxiv · Mar 19, 2025 · PreprintBiochemistry