Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements
Oriane Pourchet, Marie‐Pierre Morel, Quentin Welniarz, Nadège Sarrazin, Fabio Marti, Nicolas Heck, Cécile Galléa, Mohamed Doulazmi, Sergi Roig‐Puiggros, Juan Antonio Moreno‐Bravo, Marie Vidailhet, Alain Trembleau, Philippe Fauré, Alain Chédotal, Emmanuel Flamand Roze, Isabelle Dusart
This study shows that loss of floor plate Netrin-1 disrupts corticospinal tract midline crossing in mice, causing mirror movements similar to human congenital conditions.
Cell Reports · Jan 1, 2021Peer-reviewedNeuroscience