Emmanuel Flamand Roze

Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia

This study uses mouse models to investigate the role of Gnal loss in specific striatal projection neurons, revealing distinct effects on motor behavior and drug responses.

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights from Large-Scale Exome Sequencing

This study uses exome sequencing to identify genetic variants in dystonia patients, finding 137 likely pathogenic variants in 51 genes and expanding the known phenotypic spectrum of dystonia-related genes.

COVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system

This study investigates SARS-CoV-2 infection in the olfactory system, showing viral persistence and inflammation linked to prolonged loss of smell in COVID-19 patients.

Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements

This study shows that loss of floor plate Netrin-1 disrupts corticospinal tract midline crossing in mice, causing mirror movements similar to human congenital conditions.