Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors
Kourosh Hayatigolkhatmi, Riccardo Valzelli, Elena Ceccacci, Amir Hosseini, Oualid El Menna, Mauro Romanenghi, Isabella Pallavicini, Emanuel Soda, Ornella Ejlli, Emanuela Villa, Paolo Falvo, Pedro Vizán, Enrique Blanco, Sergi Aranda, Roxana Barkhordar, , Saverio Minucci
This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.
bioRxiv · Sep 6, 2026 · PreprintCancer Biology