SorCS2 binds progranulin and regulates motor axon outgrowth
Pernille Bogetofte Thomasen, A Salašová, Hande Login, Sander Beel, Jeppe Tranberg-Jensen, Per Qvist, P L Ovesen, S Nolte, Lene Niemann Nejsum, Moses V. Chao, Jeremy S. Dasen, Philip Van Damme, Kasper Kjær-Sørensen, Claus Oxvig, Anders Nykjær
This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.
bioRxiv · Feb 8, 2023 · PreprintDevelopmental Biology