Jeremy S. Dasen

This study shows PHC2-dependent PRC1 assemblies stabilize Hox gene boundaries and motor neuron identities during development.

This study shows that while spinal somatosensory circuit organization is conserved in skates, molecular programs specifying sensory neuron subtypes are distinct from mammals.

The paper identifies spinal-projecting serotonergic neurons that enhance locomotor speed and duration through context-dependent activity and prolonged neuromodulatory effects.

The paper shows that spinal neuron diversity increases exponentially during frog metamorphosis as motor behavior shifts from swimming to limb use, with molecular similarities to mammalian circuits.

The paper identifies molecular signatures and transcription factors that determine functional subtypes of motor neurons in zebrafish, showing their role in fast MN development.

The paper benchmarks PIPseq, a single-cell RNA sequencing method, across different scales and models, showing its ability to detect cell types and differentially expressed genes.

This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.

The paper shows that PRC1 maintains neuronal subtype identity independently of PRC2, by preserving chromatin topology and transcriptional memory during differentiation.

The paper investigates how posterior HOX TFs differ in their ability to bind inaccessible chromatin, leading to distinct gene expression patterns during motor neuron differentiation.

The paper identifies Hox gene-dependent mechanisms that govern the molecular diversity and connectivity of spinocerebellar tract neurons (SCTNs) involved in proprioception.