Moses V. Chao

Astrocytes mediate a positive feedback loop for oxytocin

The paper shows that astrocytes mediate a positive feedback loop for oxytocin by upregulating its expression through retinoic acid synthesis.

Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling

The paper shows microglia support neuronal protein synthesis by coordinating metabolic coupling in response to increased demand from motor tasks.

Astrocytes connect specific brain regions through plastic gap junctional networks

The paper shows astrocyte gap junction networks selectively connect specific brain regions and reorganize after sensory deprivation in mice.

Mapping the spatiotemporal dynamics of de novo protein synthesis during long-term memory formation

This study maps the spatiotemporal dynamics of de novo protein synthesis in mice brains after auditory threat conditioning using a novel labelling technique.

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human

The paper identifies Myocilin as a marker for glia limitans superficialis astrocytes in mouse and human, showing their specialized morphology and evolutionary conservation.

SorCS2 binds progranulin and regulates motor axon outgrowth

This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.

Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery

This paper develops and validates caged oxytocin analogs that can be activated with light to precisely control oxytocin signaling in the brain and peripheral tissues.

Oxytocin attenuates microglial activation and restores social and non-social memory in the APP/PS1 mouse model of Alzheimer's disease

This study shows that oxytocin reduces microglial activation and improves memory in Alzheimer's disease mouse models.

Topoisomerase 2-dependent nuclear DNA damage shapes extracellular growth factor responses through AKT phosphorylation dynamics to control virus latency

The paper shows that Topoisomerase 2-dependent DNA damage and AKT phosphorylation dynamics regulate HSV-1 latency by integrating extracellular signals and nuclear DNA damage.