Author

P. A. Coulombe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. A. Parent· 2 shared A. G. Zieman· 1 shared B. G. Poll· 1 shared C. M. Pineda· 1 shared C. N. Johnson· 1 shared C. Redmond· 1 shared C.-H. Lee· 1 shared D. B. Lombard· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

C. A. Parent

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Author profile →

5 papers

Recent·Most cited

Keratin 17- and PKCα-dependent transient amplification of neutrophil influx after repeated stress to the skin

Y. Xu, E. Cohen, C. N. Johnson, C. A. Parent, P. A. Coulombe

The paper identifies a keratin 17- and PKCα-dependent mechanism that transiently amplifies neutrophil influx in stressed skin, revealing a novel pathway in chronic inflammatory skin diseases.

bioRxiv · Oct 11, 2023Immunology

Keratin 17 regulates nuclear morphology and chromatin organization

J. T. Jacob, R. R. Nair, B. G. Poll, C. M. Pineda, R. P. Hobbs, M. J. Matunis, P. A. Coulombe

This study shows that Keratin 17 regulates nuclear morphology, chromatin organization, and cell proliferation in epithelial cells.

bioRxiv · Jul 16, 2020Cell Biology

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

K. Steen, D. Chen, F. Wang, S. Chen, S. Kumar, D. B. Lombard, R. Weigert, A. G. Zieman, C. A. Parent, P. A. Coulombe

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

bioRxiv · Mar 10, 2020Cell Biology

Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3sigma and YAP1

Y. Guo, K. A. Leacock, C. Redmond, V. Jaskula-Ranga, P. A. Coulombe

This study shows that K14-dependent disulfides regulate epidermal homeostasis and barrier function through interactions with 14-3-3sigma and YAP1.

bioRxiv · Oct 30, 2019Cell Biology

Structure-function analyses of a keratin heterotypic complex identify specific keratin regions involved in intermediate filament assembly

C.-H. Lee, M.-S. Kim, S. Li, D. J. Leahy, P. A. Coulombe

The paper determines the crystal structure of a keratin 5 and 14 2B domain complex and identifies key interactions critical for intermediate filament assembly.

bioRxiv · Oct 29, 2019Biochemistry